Bisglycine iron(II) salt
Iron, bis(glycinato-kN,kO)-
CAS: 20150-34-9
Molecular Formula: C4H6FeN2O4
Bisglycine iron(II) salt - Names and Identifiers
Bisglycine iron(II) salt - Physico-chemical Properties
| Molecular Formula | C4H6FeN2O4 |
| Molar Mass | 201.95 |
| Density | 1.898 at 20℃ |
| Melting Point | >162°C (dec.) |
| Boling Point | 150℃ at 101kPa |
| Flash Point | 99.5 °C |
| Solubility | Aqueous Acid (Slightly) |
| Vapor Presure | 0-0Pa at 20-25℃ |
| Appearance | Solid |
| Color | Pale Brown to Brown |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Stability | Hygroscopic |
Bisglycine iron(II) salt - Risk and Safety
| Toxicity | LD50 orally in rats: 560 mg iron/kg (Jeppsen) |
Bisglycine iron(II) salt - Reference Information
| LogP | -3.47 at 20℃ and pH7 |
| surface tension | 72.87mN/m at 1g/L and 20 ℃ |
| iron deficiency anemia treatment drugs | iron is an important raw material for the production of hemoglobin in the human body, and the demand for iron during pregnancy will be higher. Iron deficiency anemia is currently the most common type of nutritional deficiency, which is prone to occur during pregnancy. Ferrous glycine is a drug used to treat iron deficiency anemia. Ferrous glycine is a light yellow-brown-green crystalline powder with a long shelf life and will not deteriorate easily. ferrous glycine does not have the iron smell of other iron agents, and is odorless and soluble organic iron. The production method of ferrous glycine is mainly obtained by the reaction of glycine and reduced iron. The main physiological function of ferrous glycine is to prevent and improve iron deficiency anemia. The absorption rate of ferrous glycine is very high, and it can also promote the absorption of calcium, zinc, selenium and other elements. Adding to food will not cause food to change taste. Iron deficiency has become a common disease, especially iron deficiency poverty, which occurs mostly in pregnant women and children. |
| product characteristics | medical research shows that amino acid chelated iron has high bioavailability in human body, which is equivalent to the 125% of ferrous sulfate at the same level -- 185%(Henry and Miller,1995). Ferrous glycine chelate is a metal amino acid chelate formed by covalent bonding of soluble iron salt and amino acid in a molar ratio of 1:2. Glycine is the amino acid with the smallest molecular weight, which is theoretically easier to be absorbed and utilized in the body (Ashmead et al.,2001). In the United States, ferrous glycine has been used as a new nutritional iron reinforcing agent in infant dairy products and foods (Fox et al.,1998;Oscar and Ashmead,2001;Allen et al.,2002). Compared with ferrous sulfate, it has better biological utilization rate. Ferrous glycine is a real amino acid chelate, so the chemical structure is extremely stable and can pass through the digestive tract mucosa completely without dissociation in the stomach. At the same time, the small molecular structure and higher absorption and utilization rate provide hemopoiesis and iron-carrying glycine. The bioavailability is as high as 90% or more, which is more than 3-5 times that of ordinary iron. Does not cause gastrointestinal reactions. |
| use | ferrous glycine is an amino acid chelate. its unique small molecule group can pass through the digestive tract mucosa completely. compared with other iron supplement fortifiers, it has the characteristics of good palatability, small side effects and high absorption rate, and is easy to be absorbed by human body. it is an ideal iron nutrition fortifier, which is of great significance to prevent iron nutrition deficiency and improve health. At the same time, it exists in the form of chelated iron, which is absorbed autonomously in the organism, does not interact with other foods, and is safe, stable and effective. |
| preparation | weigh 0.1mol ferrous oxalate, heat to 300 ℃ under the condition of isolating air, keep for 60 minutes for reaction, and cool to room temperature to obtain active ferrous oxide after reaction is completed; Put active ferrous oxide, 0.25mol glycine and 0.75g citric acid into a 250ml conical flask, and then add 50ml of deionized water to it, and add a certain amount of liquid paraffin to the water surface. Heat to 70 ℃ in water bath and stir at constant temperature for 6 hours. After the reaction is over, the reaction solution is separated from the liquid paraffin with a separatory funnel, the reaction solution is filtered, and then 400ml of ethanol is added to the filtrate, and the precipitate is obtained after standing for 4 hours, and the precipitate is at 50 ℃ Drying for 8 hours to obtain 18.2g of ferrous glycine product with a yield of 75.9%. The total iron content was 21.0% and the ferrous iron content was 20.5%. The alcohol solution is rectified at 60 ℃ for 1.5 hours to obtain recovered ethanol, and the rest is the rectification kettle liquid. The recovered ethanol is used for alcohol analysis again, and the rectification kettle liquid and filter residue are reused. |
| biological activity | Ferrous bisglycinate (Iron glycinate) is the source compound of dietary iron. It is a chelate and also has a nutritional function. |
| Cell Line: | Caco-2 cells Caco-2 cells |
| Concentration: | 0, 25, 50, 100, 200 μM 25 μM |
| Incubation Time: | 2 hours 2 hours |
| Result: | Did not affect the viability of wild-type and divalent metal transporter 1 (DMT1) knockout Caco-2 cells. Increased ferritin content and decreased DMT1 expression levels significantly in the wild-type cells. Had the best survival rates (100%). Caused the least body lost (9% body loss). |
| Animal Model: | Female C57BL/6 mice are induced colitis by dextran sodium sulfate (DSS) |
| Dosage: | 500 mg/kg iron |
| Administration: | P.o. (add to the diet) for 10 days |
Last Update：2024-04-09 15:16:48
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